NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. Extended follow-up of the DART-AD trial found patients with Alzheimer’s disease who continued antipsychotic medication for behavioural or psychiatric problems were twice as likely to die as those switched […]
Category Archives: CNS and mental health
NPC Archive Item: Tasimelteon for insomnia – early data in healthy people with an artificially disturbed sleep pattern.
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. In healthy people whose sleep pattern had been brought forward by five hours, a single dose of tasimelteon reduced the time to persistent sleep compared to placebo. It is […]
NPC Archive Item: Z-drugs increase the risk of road traffic accidents
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. A study in Norway has found that prescription of Z-drugs is associated with around a doubled increased relative risk of road traffic accidents compared to those who don’t take […]
NPC Archive Item: EMEA reinforces safety concerns over using antipsychotics in elderly patients with dementia
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. The EMEA has reported that, as with newer (atypical) antipsychotics, conventional (typical) antipsychotics are likely to be associated with increased mortality when used in elderly people with dementia. Action […]
NPC Archive Item: No difference in effectiveness of ‘second-generation’ antidepressants
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. A recent systematic review concludes that current evidence does not support the choice of one second-generation antidepressant (e.g. SSRIs, venlafaxine, duloxetine▼, mirtazapine) over another on the basis of efficacy […]
NPC Archive Item: Olanzapine long-acting injection for schizophrenia
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. EMEA Summary of Positive Opinion for olanzapine long-acting injection (Zypadhera ®) In September 2008, the Committee for Medicinal Products for Human Use (CHMP) recommended European licensing approval of olanzapine […]
NPC Archive Item: Concomitant use of an SSRI and NSAID increases the risk of an upper GI bleed six times
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. Loke YK, Trivedi AN, Singh S. Meta-analysis: gastrointestinal bleeding due to interaction between selective serotonin reuptake inhibitors and non-steroidal anti-inflammatory drugs. Aliment Pharmacol Ther 2008;27:31–40 The relative risk of […]
NPC Archive Item: More evidence that antipsychotics increase stroke risk
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. Douglas IJ, Smeeth L. Exposure to antipsychotics and risk of stroke: self controlled case series study. BMJ 2008;337:a1227 A recent study adds to evidence that typical and atypical antipsychotics are […]
NPC Archive Item: The Healthcare Commission’s Survey of Users of Mental Health Services 2008
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. What is the background to this? The Healthcare Commission’s survey of users of mental health services 2008 has now been published This is the 5th survey of its kind […]
NPC Archive Item: NICE issues guidance on ADHD
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. NICE Guidance on attention deficit hyperactivity disorder. Clinical Guideline No.72. September 2008 NICE has issued guidance on the diagnosis and management of attention deficit hyperactivity disorder (ADHD) in children […]