NPC Archive Item: Antipsychotics increase mortality in patients with Alzheimer’s disease

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. Extended follow-up of the DART-AD trial found patients with Alzheimer’s disease who continued antipsychotic medication for behavioural or psychiatric problems were twice as likely to die as those switched […]

NPC Archive Item: Z-drugs increase the risk of road traffic accidents

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. A study in Norway has found that prescription of Z-drugs is associated with around a doubled increased relative risk of road traffic accidents compared to those who don’t take […]

NPC Archive Item: No difference in effectiveness of ‘second-generation’ antidepressants

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. A recent systematic review concludes that current evidence does not support the choice of one second-generation antidepressant (e.g. SSRIs, venlafaxine, duloxetine▼, mirtazapine) over another on the basis of efficacy […]

NPC Archive Item: Olanzapine long-acting injection for schizophrenia

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. EMEA Summary of Positive Opinion for olanzapine long-acting injection (Zypadhera ®) In September 2008, the Committee for Medicinal Products for Human Use (CHMP) recommended European licensing approval of olanzapine […]