NPC Archive Item: Antipsychotics increase mortality in patients with Alzheimer’s disease

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. Extended follow-up of the DART-AD trial found patients with Alzheimer’s disease who continued antipsychotic medication for behavioural or psychiatric problems were twice as likely to die as those switched […]

NPC Archive Item: Z-drugs increase the risk of road traffic accidents

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. A study in Norway has found that prescription of Z-drugs is associated with around a doubled increased relative risk of road traffic accidents compared to those who don’t take […]

NPC Archive Item: No difference in effectiveness of ‘second-generation’ antidepressants

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. A recent systematic review concludes that current evidence does not support the choice of one second-generation antidepressant (e.g. SSRIs, venlafaxine, duloxetine▼, mirtazapine) over another on the basis of efficacy […]

NPC Archive Item: Olanzapine long-acting injection for schizophrenia

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. EMEA Summary of Positive Opinion for olanzapine long-acting injection (Zypadhera ®) In September 2008, the Committee for Medicinal Products for Human Use (CHMP) recommended European licensing approval of olanzapine […]

NPC Archive Item: Concomitant use of an SSRI and NSAID increases the risk of an upper GI bleed six times

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. Loke YK, Trivedi AN, Singh S. Meta-analysis: gastrointestinal bleeding due to interaction between selective serotonin reuptake inhibitors and non-steroidal anti-inflammatory drugs. Aliment Pharmacol Ther 2008;27:31–40 The relative risk of […]

NPC Archive Item: More evidence that antipsychotics increase stroke risk

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. Douglas IJ, Smeeth L. Exposure to antipsychotics and risk of stroke: self controlled case series study. BMJ 2008;337:a1227 A recent study adds to evidence that typical and atypical antipsychotics are […]