NPC Archive Item: Inhaled corticosteroids and the risk of diabetes

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 8th February 2011 A Canadian cohort study identified that patients treated for respiratory disease using inhaled corticosteroids (ICS) over a period of 5.5 years were, on average, at a 34% […]

NPC Archive Item: Comparative safety of ICS/LABA combinations in chronic asthma

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 3 June 2010 A Cochrane review found no significant difference in serious adverse events when different combinations of inhaled corticosteroids and long-acting beta2 agonists were compared in people with chronic […]

NPC Archive Item: Tiotropium in asthma – still no good evidence for routine use

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 11 November 2010 A US exploratory study in 210 patients examined the effects of tiotropium in poorly controlled asthma. While hypothesis generating, the study does not provide grounds for clinicians […]

NPC Archive Item: Oral roflumilast▼ launched as add-on treatment for COPD

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 13 October 2010 Roflumilast▼ has been marketed as a once daily add-on treatment to bronchodilator therapy in patients with severe chronic obstructive pulmonary disease (COPD) who have frequent exacerbations. Weight […]

NPC Archive Item: Inhaled corticosteroids more effective than montelukast in reducing asthma exacerbations in children

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 10 September 2010 A meta-analysis has found that inhaled corticosteroids are significantly more effective than montelukast for preventing severe asthma exacerbations requiring systemic corticosteroids in schoolchildren and adolescents with mild-moderate […]

NPC Archive Item: Key licensing studies for indacaterol in COPD published

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 31 August 2010 Indacaterol▼ inhaled once daily improved trough FEV1 at 12 weeks compared to placebo in patients with moderate to severe COPD. Results from the 52-week INVOLVE study […]

NPC Archive Item: FDA rejects application for roflumilast in COPD, but previous CHMP positive opinion

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 24 June 2010 The FDA has recently rejected a New Drug Application for roflumilast (Daxas®), which was in licensing to reduce exacerbations associated with chronic obstructive pulmonary disease (COPD). Further […]

NPC Archive Item: Antibiotic strategy for preventing complications of sore throat in young people

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. A recent article highlights that Fusobacterium necrophorum is the cause of around 10% of acute pharyngitis cases in adolescents and young adults. One of the supparative complications of this […]

NPC Archive Item: Phase out of chlorofluorocarbon (CFC)-containing pharmaceutical metered dose inhalers

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 7 May 2010 Introduction: Pharmaceutical metered dose inhalers (pMDIs) traditionally used chlorofluorocarbons (CFCs) as the propellant but, under the 1987 Montreal Protocol on Substances that Deplete the Ozone Layer1, […]

NPC Archive Item: Cardiovascular safety of anticholinergics in COPD

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 25 March 2010 A US cohort study in patients with COPD found an increased risk of CV events associated with the use of ipratropium within the past six months. […]