Category Archives: Cardiovascular disease

NPC Archive Item: Coxibs or traditional NSAIDs for patients on low dose aspirin?

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. Strand V. Are COX-2 inhibitors preferable to non-selective non-steroidal anti-inflammatory drugs in patients with risk of cardiovascular events taking low-dose aspirin? Lancet 2007;370:2138–51 A recent review article in the […]

NPC Archive Item: Varenicline▼ safety update

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. The Medicines and Healthcare products Regulatory Agency has announced an update to the product information for varenicline (Champix® ▼) highlighting concerns over suicidal thoughts and behaviour. Following a European […]

NPC Archive Item: Cardiovascular safety of glitazones in older people

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. Lipscombe L, Gomes T, Lévesque LE, et al. Thiazolidinediones and cardiovascular outcomes in older patients with diabetes. JAMA. 2007;298:2634-43. A large population-based study from Canada increases concerns over the […]

NPC Archive Item: Ezetimibe▼ in hypercholesterolaemia: NICE guidance

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. What is this about? NICE has published a technology appraisal covering ezetimibe▼ in hypercholesterolaemia. What do NICE say? NICE guidance relates only primary (heterozygous-familial or non-familial) hypercholesterolaemia, and not […]

NPC Archive Item: Current volume of angiotensin receptor blockers (ARBs) prescribing is not justified by the evidence

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. Matchar DB, McCrory DC, Orlando LA, et al. Comparative Effectiveness of Angiotensin-Converting Enzyme Inhibitors (ACEIs) and Angiotensin II Receptor Antagonists (ARBs) for Treating Essential Hypertension. Comparative Effectiveness Review No. […]

NPC Archive Item: Treat TIAs and minor strokes urgently

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. Rothwell PM et al. Effect of urgent treatment of transient ischaemic attack and minor stroke on early recurrent stroke (EXPRESS study): a prospective population-based sequential comparison. Lancet Neurology Published […]

NPC Archive Item: Warfarin more effective than aspirin for stroke risk in AF but what about the risk of bleeding? – The BAFTA study

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. Warfarin versus aspirin for stroke prevention in an elderly community population with atrial fibrillation (the Birmingham Atrial Fibrillation Treatment of the Aged Study, BAFTA): a randomised controlled trial What […]