NPC Archive Item: NICE publishes clinical guidance on management of rheumatoid arthritis

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 27th February 2009 The NICE guideline (CG79) covers the management of rheumatoid arthritis (RA) of recent onset and more established disease. It includes sections on diagnosis and referral, pharmacological […]

NPC Archive Item: All non-analgesic drug classes are similarly effective in the treatment of neuropathic pain

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 26th January 2009 A Canadian Health Technology Assessment concludes that, in patients with neuropathic pain, there is no statistically significant difference in clinical response rates between tricyclic antidepressants, anticonvulsants […]

NPC Archive Item: Tocilizumab plus methotrexate studied in refractory RA (RADIATE)

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. Emery P et al. Annals of the Rheumatic Diseases 2008;67:1516–1523 Tocilizumab with methotrexate was more effective than placebo and methotrexate at increasing ACR20 response rates in patients with moderate […]

NPC Archive Item: Concomitant use of an SSRI and NSAID increases the risk of an upper GI bleed six times

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. Loke YK, Trivedi AN, Singh S. Meta-analysis: gastrointestinal bleeding due to interaction between selective serotonin reuptake inhibitors and non-steroidal anti-inflammatory drugs. Aliment Pharmacol Ther 2008;27:31–40 The relative risk of […]

NPC Archive Item: No reason to stop using paracetamol in children

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. Beasley R et al. Association between paracetamol use in infancy and childhood, and risk of asthma, rhinoconjunctivitis and eczema in children aged 6-7 years: analysis from Phase Three of […]

NPC Archive Item: No good evidence for combination antipyretics in children

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. Hay AD, Costelloe C, Redmond NM, et al. Paracetamol plus ibuprofen for the treatment of fever in children (PITCH): randomised controlled trial. BMJ 2008;337:a1302 A combination of paracetamol plus […]

NPC Archive Item: Withdrawal of co-proxamol linked to reduced suicides in Scotland

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. Sandilands EA & Bateman DN. Co-proxamol withdrawal has reduced suicides from drugs in Scotland. Br J Clin Pharmacol 2008;66:290–3 The withdrawal of co-proxamol has been accompanied by a significant […]