NPC Archive Item: CV risk of diclofenac similar to rofecoxib

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 6 July 2010 A large cohort study found that individual NSAIDs have different levels of CV risk. In particular, this study found that diclofenac and rofecoxib were associated with a […]

NPC Archive Item: June Drug Safety Update from MHRA/CHM

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. The Drug Safety Update is an NHS Evidence accredited provider 11th June 2009 The MHRA and CHM have published the June edition of Drug Safety Update. This issue gives […]

NPC Archive Item: Encouraging prescribing trends for NSAIDs

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 9th March 2009 Since November 2007 there has been a significant change in the prescribing rate of diclofenac (a decline of about 5% of total NSAID items per year) […]

NPC Archive Item: Rofecoxib is associated with an early increase in cardiovascular events, which persists for a year after stopping treatment

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. Baron J, Sandler RS, Bresalier RS, et al. Cardiovascular events associated with rofecoxib: final analysis of the APPROVe trial. The Lancet. Early online publication 14th October 2008. DOI:10.1016/S0140-6736(08)61490–7 In the […]

NPC Archive Item: Concomitant use of an SSRI and NSAID increases the risk of an upper GI bleed six times

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. Loke YK, Trivedi AN, Singh S. Meta-analysis: gastrointestinal bleeding due to interaction between selective serotonin reuptake inhibitors and non-steroidal anti-inflammatory drugs. Aliment Pharmacol Ther 2008;27:31–40 The relative risk of […]

NPC Archive Item: Gastroprotection – no protective advantage for coxibs over traditional NSAIDs among elderly patients on a PPI

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. Abraham NS, Hartman C, Castillo D, et al. Effectiveness of national provider prescription of PPI gastroprotection among elderly NSAID users. Am J Gastroenterol 2008;103:323-32 Limited observational data question using […]