Rapid Update 2 – June 2020: Osteoarthritis of the knee: randomised study compares corticosteroid injections with physical therapy.

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Rapid Update 1- June 2018: Opioids: interventions to reduce use in chronic non-cancer pain

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Rapid Update 3- September 2017: Osteoarthritis: systematic review and individual patient data meta-analysis finds no good evidence to support the use of glucosamine

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Rapid Update 2- June 2017: NSAIDs and risk of acute myocardial infarction

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Rapid Update 1 – April 2017: Pain: meta-analysis finds limited efficacy of non-steroidal anti-inflammatory drugs (NSAIDs) for spinal pain

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Rapid Update 3 – December 2016: Cardiovascular safety of celecoxib, naproxen, or ibuprofen for arthritis

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Osteoarthritis: evidence review of paracetamol raises further doubts about its effectiveness (and safety) (Apr-15)

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NPC Archive Item: New evidence for naproxen/esomeprazole▼ combination in knee osteoarthritis.

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 25 November 2011 Two 12-week phase III studies found that a fixed-dose combination of naproxen and esomeprazole (Vimovo▼) had comparable upper gastrointestinal (GI) tolerability to celecoxib in people with […]

NPC Archive Item: Even short-term NSAID use can increase cardiovascular risk in patients with prior MI

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 16 June 2011 A Danish cohort study identified an increased risk of death or recurrent myocardial infarction (MI) with non-steroidal anti-inflammatory drugs (NSAIDs) in patients with prior MI. The […]

NPC Archive Item: NSAIDs and cardiovascular risks – more evidence, but this shouldn’t be new news

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 1st February 2011 The conclusions of a network meta-analysis of randomised trials broadly confirm previous research showing an increased risk of cardiovascular (CV) events with many NSAIDs. Naproxen was […]