NPC Archive Item: Increased death rate found in intensive blood glucose-lowering arm of trial in type 2 diabetes – study arm halted

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. Yesterday the National Heart Lung and Blood Institute (NHLBI) in the USA announced that it has stopped the intensive blood-glucose-lowering arm of a large type 2 diabetes trial due […]

NPC Archive Item: Statins for all patients with diabetes?

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. Cholesterol Treatment Trialist’s Collaborators. Efficacy of cholesterol-lowering in 18,686 people with diabetes in 14 randomised trials of statins: a meta-analysis. Lancet 2008;371: 117–25 What is the background to this? […]

NPC Archive Item: Has reaction against “glucocentricity” in type 2 diabetes “gone too far”?

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. Bailey C, Barnett A and Petrie J. Value of glycaemic control in diabetes. Lancet 2008; 371:116 What is all this about? In a recent letter to The Lancet, three […]

NPC Archive Item: Cardiovascular safety of glitazones in older people

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. Lipscombe L, Gomes T, Lévesque LE, et al. Thiazolidinediones and cardiovascular outcomes in older patients with diabetes. JAMA. 2007;298:2634-43. A large population-based study from Canada increases concerns over the […]

NPC Archive Item: NPC Podcast – 22nd November 2007

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. Fibrates in type 2 diabetes; ARBs overused?; psychiatric reactions with rimonabant; evidence for wound care products [podcast]http://www.npc.nhs.uk/podcast/NPCiPodcast_22ndNov07.mp3[/podcast] Subscribe to the NPC podcast via the iTunes store Subscribe to the […]

NPC Archive Item: Fenofibrate in type 2 diabetes – reduces need for laser eye treatment, but no effect on visual acuity (or coronary event rate or mortality)

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. Keech AC et al. Effect of fenofibrate on the need for laser treatment for diabetic retinopathy (FIELD study): a randomised controlled trial Lancet 2007, published online 6th November DOI:10.1016/S0140-6736(07)61607-9 […]

NPC Archive Item: Fibrates not first choice drugs for most patients, say MHRA and CHM

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. Fibrates should not be used as first line lipid-lowering drugs for primary or secondary prevention of cardiovascular disease. So say the MHRA and CHM in the most recent issue […]

NPC Archive Item: Vildagliptin launch delayed

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. The European launch of vildagliptin (Glavus®) has been delayed by a safety update according to PharmaTimes. Pooled safety data shows more frequent liver enzyme elevations with the 100mg once daily […]

NPC Archive Item: Diabetes news – safety review of glitazones; inhaled insulin discontinued.

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. The Medicines and Healthcare products Regulatory Agency have announced the outcome of a Europe wide safety review of the glitazones. The review found a positive benefit-risk balance for both […]

NPC Archive Item: Better HbA1c control with biphasic or prandial insulin than basal insulin in type 2 diabetes, but more weight gain and hypoglycaemia

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. Holman R et al. Addition of biphasic, prandial or basal insulin to oral therapy in type 2 diabetes. N Engl J Med 2007; 357. Published on line on September […]