NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 12 November 2009 This systematic review found that adding an ACE inhibitor to standard medical therapy reduces the risk of certain serious CV outcomes in patients with stable ischaemic […]
Category Archives: Cardiovascular disease
NPC Archive Item: Dronedarone is less effective, but safer than amiodarone in atrial fibrillation
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 27 October 2009, An indirect comparison meta-analysis found that dronedarone was significantly less effective than amiodarone in preventing recurrence of AF, but was associated with fewer side effects requiring […]
NPC Archive Item: Dabigatran▼ vs. warfarin for prevention of stroke in atrial fibrillation: the RE-LY study
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 27 October 2009, The RE-LY study found that, in patients with atrial fibrillation with at least one other risk factor for stroke, dabigatran▼ was non-inferior to adjustable dose warfarin […]
NPC Archive Item: October Drug Safety Update from MHRA/CHM
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. The Drug Safety Update is an NHS Evidence accredited provider 15 October 2009 The MHRA and CHM have published the October edition of Drug Safety Update. There is a […]
NPC Archive Item: Ticagrelor — another antiplatelet for ACS
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 2 December 2009 Ticagrelor plus aspirin was significantly more effective than clopidogrel plus aspirin in preventing vascular events in patients with acute coronary syndrome in the PLATO trial (NNT=53). […]
NPC Archive Item: New eLearning resource for VTE
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 2nd October 2009 The Chief Medical Officer’s Venous Thromboembolism (VTE) Implementation Working Group and eLearning for Healthcare have published a web-based education resource (e-VTE) designed to help raise awareness […]
NPC Archive Item: What blood pressure target in hypertension, and which drug to try first?
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 2nd October 2009 Two Cochrane reviews have addressed these questions. The review of blood pressure (BP) targets for hypertension concluded that treating patients to achieve BPs of less than […]
NPC Archive Item: Reducing heart rate, not increasing beta-blocker dose, improves survival in heart failure
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 22 September 2009 This meta-analysis found that heart rate reduction was significantly associated with survival benefit in patients in beta-blocker chronic heart failure trials, whereas the dose of beta-blocker […]
NPC Archive Item: Clopidogrel plus PPIs: doubts about clinical relevance of interaction
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 11th September 2009 This analysis of two studies found that, although PPIs attenuated the in-vitro antiplatelet effects of clopidogrel and prasugrel▼, the combination was not associated with an increased […]
NPC Archive Item: A BP target for systolic blood pressure of 130mmHg?
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 21 August 2009 The Cardio-Sis study found that tight control of systolic hypertension (<130mmHg) decreased the likelihood of left ventricular hypertrophy and a composite of clinical events, compared with […]