NPC Archive Item: Ezetimibe▼ doesn’t ENHANCE statins

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. What is this about? The results (login required) of the ENHANCE Study have found no significant difference between the combination of ezetimibe▼ and simvastatin compared to simvastatin alone in […]

NPC Archive Item: Is QRISK a better way to assess cardiovascular risk?

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. Hippisley-Cox J, et al.  Performance of the QRISK cardiovascular risk prediction algorithm in an independent UK sample of patients from general practice: a validation study. Heart 2008; 94: 34-39. […]

NPC Archive Item: Calcium supplements may increase the risk of MI

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. Bolland MJ, Barber PA, Doughty RN, et al. Vascular events in healthy older women receiving calcium supplementation: randomised controlled trial. BMJ Online First doi:10.1136/bmj.39440.525752.BE (published 15 January 2008) What […]

NPC Archive Item: Coxibs or traditional NSAIDs for patients on low dose aspirin?

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. Strand V. Are COX-2 inhibitors preferable to non-selective non-steroidal anti-inflammatory drugs in patients with risk of cardiovascular events taking low-dose aspirin? Lancet 2007;370:2138–51 A recent review article in the […]

NPC Archive Item: Varenicline▼ safety update

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. The Medicines and Healthcare products Regulatory Agency has announced an update to the product information for varenicline (Champix® ▼) highlighting concerns over suicidal thoughts and behaviour. Following a European […]

NPC Archive Item: Cardiovascular safety of glitazones in older people

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. Lipscombe L, Gomes T, Lévesque LE, et al. Thiazolidinediones and cardiovascular outcomes in older patients with diabetes. JAMA. 2007;298:2634-43. A large population-based study from Canada increases concerns over the […]

NPC Archive Item: Ezetimibe▼ in hypercholesterolaemia: NICE guidance

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. What is this about? NICE has published a technology appraisal covering ezetimibe▼ in hypercholesterolaemia. What do NICE say? NICE guidance relates only primary (heterozygous-familial or non-familial) hypercholesterolaemia, and not […]